A.A. Zadpoor1, H. Weinans2
1Delft University of Technology (TU Delft)/NL, 2Erasmus Medical Center/NL
Two important mechanical concepts, namely mechanical force and motion, play tremendously important roles in the function, growth, differentiation, and adaptation of different types of living tissues such as connective and muscle tissues. Due to the highly hierarchical structure of tissues, the consequences of the mechanical forces and motions are transferred back and forth along several time and spatial scales. The mechanical behavior of tissues is therefore studied not only at the tissue scale but also in relation with cells and proteins in a multi-scale modeling scheme.
The environment in which cells and tissues lives also plays an important role. Therefore, the mechanical interactions between cells and tissues and their surrounding living entities (other cells and tissues) and/or synthetic biomaterials need to be studied as well. The synthetic biomaterials may have been used for replacement of some of the tissues (implants) or regeneration of tissues in the laboratory (scaffolds, etc.).
This mini-symposium aims to bring together researchers who study cells and tissues at different length and time scales using either single- or multi-scale computational models. The methodology may be finite element, boundary element, molecular dynamics, or any combination of these methods. The mini-symposium considers (but is not limited to) contributions in the following areas of research: