MS624 Computational mechanics of biological tissues

undefinedE. Budyn1, T. Hoc2, P. Pivonka3, R. Krams4
1University of Illinois as Chicago/US, 2Ecole Centrale Lyon/FR, 3The University of Western Australia/AU, 4Imperial College/UK


Recent technological advances in experimental techniques have taken the investigation of the mechanics of biological tissues down to the nanometer scale. To complement fundamental experimental research on biological tissues, novel computational methods can support the construction of theoretical models that make it possible to understand the complexity of the constitutive behaviors of biomaterials. These computational methods also play a key role in the image processing of the experiments in particular at the cellular level to unlock essential biology function. More complete biological characterisation of these tissues includes the cellular function such as mechano-sensing and mechano-transduction. Despite the tremendous challenges these methods are facing, collaborative experimental and theoretical efforts have the potential to overcome scientific barriers quickly and transform the bioengineering community. This symposium will focus on the characterization and modeling of tissue mechanics and biology. The biological tissues considered include cardiac, connective, muscle, neural and epithelial tissues. This symposium will focus on the investigation of the mechanics of cells of the aforementioned biomaterials in relation to their physiological response modeled in the frame of mechanobiology. Are welcome solid mechanics studies of the musculoskeletal system and soft tissues as well as fluid structure interaction models for cardiovascular descriptions. Growth models to describe the mechanics at the interface between biological tissues and biocompatible materials will also be considered. Targeted themes: - Cell mechanics, mechanics of cellular sub-structure, cell biology, single cell modeling, cell interactions, cell growth, cell imaging, mechanobiology, mechanosensing and mechanotransduction. - Tissue mechanics, constitutive modeling, tissue mechanical characterization, tissue remodeling, tissue/tumor growth, tissue pathological evolution, tissue imaging, multi-scale models.



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